Key result
Pulmonary trunk diameter and its ratio to the ascending aorta measured by cardiac computed tomography both demonstrated 88.9% sensitivity for diagnosing pulmonary arterial hypertension in children.
Why the study?
Diagnostic criteria for pulmonary arterial hypertension in children using noninvasive cardiac computed tomography parameters needed to be established.
Do pulmonary trunk diameter and its ratio to the ascending aorta measured by cardiac computed tomography accurately diagnose pulmonary arterial hypertension in children?
Observational (n=208)
No
Do pulmonary trunk diameter and its ratio to the ascending aorta measured by cardiac computed tomography accurately diagnose pulmonary arterial hypertension in children?
p-value: p=< 0.01
Height-adjusted pulmonary trunk diameter and its ratio to the ascending aorta measured by cardiac CT offer high sensitivity and negative predictive value for diagnosing PAH in children.
OBJECTIVE: To establish diagnostic criteria for pulmonary arterial hypertension (PAH) in children by using parameters obtained through noninvasive cardiac computed tomography (CCT). MATERIALS AND METHODS: We retrospectively measured parameters from CCT images of children from a single institution in a multiple stepwise process. A total of 208 children with mean age of 10.5 years (range: 4 days-18.9 years) were assessed. The variables were classified into three groups: the great arteries; the ventricular walls; and the bilateral ventricular cavities. The relationship between the parameters obtained from the CCT images and mean pulmonary arterial pressure (mPAP) was tested and adjusted by the children's body size. Reference curves for the pulmonary trunk diameter (PTD) and ratio of diameter of pulmonary trunk to ascending aorta (rPTAo) of children with CCT images of normal hearts, adjusted for height, were plotted. Threshold lines were established on the reference curves. RESULTS: < 0.01). On the basis of the threshold lines on the reference curves, PTD and rPTAo both showed 88.9% sensitivity for PAH diagnosis, with negative predictive values of 93.3% and 92.9%, respectively. CONCLUSION: PTD and rPTAo measured from CCT images were significantly correlated with mPAP in children. Reference curves and the formula of PTD and rPTAo adjusted for height could be practical for diagnosing PAH in children.
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Chen et al. (2019) conducted an observational in Pulmonary arterial hypertension (n=208). Cardiac computed tomography parameters (PTD and rPTAo) was evaluated on Sensitivity for PAH diagnosis (p=< 0.01). Pulmonary trunk diameter and its ratio to the ascending aorta measured by cardiac computed tomography both demonstrated 88.9% sensitivity for diagnosing pulmonary arterial hypertension in children.
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