Key result
Endomyocardial biopsy revealed ultrastructural abnormalities indicating that degeneration of myocardial cells by autophagy mechanisms leads to cardiomyocyte death and heart failure.
Case Report (n=1)
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Ultrastructural evidence suggests that autophagic degeneration of cardiomyocytes contributes to the transition from hypertrophic cardiomyopathy to heart failure.
Endomyocardial biopsy of a patient in transition stage from hypertrophic cardiomyopathy to heart failure was investigated. The tissue showed hypertrophy, atrophy of myocytes and an increased amount of fibrosis. In addition, numerous cardiomyocytes revealed ubiquitin positive inclusions. Ultrastructural analysis indicated that cardiomyocytes contained typical autophagic vacuoles including mitochondria, glycogen granules, degraded remnants and myelin structures. The most obvious ultrastructural finding was the presence of amorphous plaques and tubulofilamentous inclusions. Such ultrastructural abnormalities allow us to conclude that degeneration of myocardial cells by autophagy mechanisms leads to cardiomyocyte death, loss and heart failure.
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Fidziańska et al. (2009) conducted a case report in Hypertrophic cardiomyopathy transitioning to heart failure (n=1). Autophagy mechanisms was evaluated on Ultrastructural abnormalities. Endomyocardial biopsy revealed ultrastructural abnormalities indicating that degeneration of myocardial cells by autophagy mechanisms leads to cardiomyocyte death and heart failure.
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