Global Thrombosis Test: Occlusion Is Attributable to Shear-Induced Platelet Thrombus Formation

We read the paper by Clavería and co-workers with interest.[ 1 ] We strongly believe that the conclusions of their paper, suggesting that occlusion (occlusion time (OT)) in the global thrombosis test (GTT) is due to coagulation, rather than shear-induced platelet thrombus formation, is wrong and the evidence and arguments they present are fundamentally flawed. The authors have made major errors both in the approach to their experiments and in their interpretations of their results. The evidence which they demonstrate, shows that occlusion in the GTT is, in fact, caused by high shear-induced platelet thrombus formation, the complete opposite to their interpretation of their results. We set out below the evidence for that. Publication History Received: 11 October 2021 Accepted: 16 November 2021 Accepted Manuscript online: 23 November 2021 Article published online: 15 February 2022 © 2021. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/) Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany