Key result
A novel gemycircularvirus, named GeTz1, was discovered in the cerebrospinal fluid of a child with unexplained encephalitis, though it was absent in 110 other similar cases.
Case Report (n=130)
A novel gemycircularvirus was discovered in the CSF of a child with unexplained encephalitis, though its pathogenic role in humans remains undetermined.
Single-case detection warrants diagnostic caution; leaves open any causal role in human encephalitis pending validation.
BACKGROUND: Recently, a diverse group of viruses with circular, replication initiator protein(Rep) encoding, single stranded DNA (CRESS-DNA) genomes, were discovered from wide range of eukaryotic organisms ranging from mammals to fungi. Gemycircularvirus belongs to a distinct group of CRESS-DNA genomes and is classified under the genus name of Gemycircularvirus. FINDINGS: Here, a novel gemycircularvirus named GeTz1 from cerebrospinal fluid sample of a child with unexplainable encephalitis was characterized. The novel gemycircularvirus encodes two major proteins, including a capsid protein (Cap) and a replication-associated protein (Rep). Phylogenetic analysis based on the amino acid sequence of Rep indicated that GeTz1 clusters with one gemycircularvirus discovered from bird (KF371633), sharing 46.6 % amino acid sequence identity with each other. CONCLUSION: A novel gemycircularvirus was discovered from cerebrospinal fluid sample of a child with unexplainable encephalitis. Further studies, such as testing human sera for specific antibodies, should be performed to investigate whether gemycircularvirus infects human and is associated with encephalitis.
No takes yet. Share an insight, caveat, or question.
Zhou et al. (2015) conducted a case report in Unexplainable encephalitis (n=130). Gemycircularvirus (GeTz1) was evaluated on Detection of gemycircularvirus in cerebrospinal fluid. A novel gemycircularvirus, named GeTz1, was discovered in the cerebrospinal fluid of a child with unexplained encephalitis, though it was absent in 110 other similar cases.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: