Key result
Cold gel pack application during amiodarone infusion reduced the rate of phlebitis development compared to standard care (59% vs 95%, p < .001).
Why the study?
The study was conducted to evaluate the effect of cold application on amiodarone-related vein phlebitis.
Does cold gel pack application reduce amiodarone-related phlebitis in patients receiving amiodarone infusion?
Does cold gel pack application reduce amiodarone-related phlebitis in patients receiving amiodarone infusion?
Absolute Event Rate: 59% vs 95%
p-value: p=< .001
Application of cold gel packs during amiodarone infusion significantly reduces the incidence and severity of phlebitis.
May reduce amiodarone phlebitis; hypothesis-generating and requires randomized confirmation before practice change.
The purpose of this study was to evaluate the effect of cold application on amiodarone-related vein phlebitis. A quasi-experimental design was used. The study sample consisted of 79 patients who received an amiodarone infusion. The control group of the study consisted of patients receiving amiodarone treatment, while the intervention group consisted of patients receiving cold application during the amiodarone infusion. In the intervention group, after the start of amiodarone treatment, cold gel packs were applied a total of 12 times for 15 min at 2-h intervals. The rate of phlebitis development was 59% in the intervention group and 95% in the control group (p < .001). It was found that 52.2% of the patients in the intervention group had first grade phlebitis and 84.4% of the patients in the control group who developed phlebitis had second grade phlebitis (p < .001). The 15-min cold application was found to be effective in terms of the rate of phlebitis development, phlebitis grade and time of phlebitis development. (ClinicalTrials.gov NCT05058053).
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Okyay et al. (2024) studied Amiodarone-related vein phlebitis (n=79). Cold gel pack application vs. Standard amiodarone treatment was evaluated on Rate of phlebitis development (p=< .001). Cold gel pack application during amiodarone infusion reduced the rate of phlebitis development compared to standard care (59% vs 95%, p < .001).
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