Key result
Prophylactic intravenous amiodarone infusion for 48 hours postoperatively significantly reduced the occurrence of sustained atrial fibrillation compared to saline (30.0% vs 63.6%, p=0.04).
Why the study?
Postoperative AF is associated with significant morbidity after cardiac surgery, prompting investigation into whether prophylactic amiodarone infusion can prevent it.
Does prophylactic intravenous amiodarone infusion reduce the occurrence of postoperative atrial fibrillation in high-risk patients undergoing cardiac surgery?
Population
42 patients with a high risk of postoperative AF undergoing cardiac surgery
Comparison
Prophylactic 48-hour amiodarone infusion vs saline infusion
Design
Prospective randomized study
Follow-up
One week
Authors
Loading...
May support 48-hour IV amiodarone prophylaxis; leaves open confirmation in larger randomized trials.
RCT (n=42)
Randomized
No
Does prophylactic intravenous amiodarone infusion reduce the occurrence of postoperative atrial fibrillation in high-risk patients undergoing cardiac surgery?
Absolute Event Rate: 30% vs 63.6%
p-value: p=0.04
Prophylactic intravenous amiodarone for 48 hours postoperatively significantly reduces the occurrence and duration of atrial fibrillation and shortens hospital stay in high-risk cardiac surgery patients.
Masuda et al. (2019) conducted an RCT in Postoperative atrial fibrillation (n=42). Amiodarone vs. Saline infusion was evaluated on Occurrence of sustained atrial fibrillation for ≥ 1 hr (p=0.04). Prophylactic intravenous amiodarone infusion for 48 hours postoperatively significantly reduced the occurrence of sustained atrial fibrillation compared to saline (30.0% vs 63.6%, p=0.04).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: