Key result
Prophylactic amiodarone reduced the occurrence of postoperative atrial fibrillation compared with controls (23.1% vs 29.9%, p=0.05) and lowered total hospital costs.
Why the study?
Does prophylactic amiodarone reduce postoperative atrial fibrillation and hospital costs in patients undergoing cardiothoracic surgery?
Cohort (n=2,046)
No
Does prophylactic amiodarone reduce postoperative atrial fibrillation and hospital costs in patients undergoing cardiothoracic surgery?
Absolute Event Rate: 23.1% vs 29.9%
p-value: p=0.05
Prophylactic amiodarone is a cost-effective strategy that reduces both the incidence of postoperative atrial fibrillation and total hospital costs in patients undergoing cardiothoracic surgery.
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May support prophylactic amiodarone after cardiothoracic surgery; leaves open confirmation in randomized trials.
Gillespie et al. (2006) conducted a cohort in Postoperative atrial fibrillation after cardiothoracic surgery (n=2,046). Prophylactic amiodarone vs. No prophylactic amiodarone was evaluated on Occurrence of postoperative atrial fibrillation (p=0.05). Prophylactic amiodarone reduced the occurrence of postoperative atrial fibrillation compared with controls (23.1% vs 29.9%, p=0.05) and lowered total hospital costs.