Why the study?
Does amiodarone prophylaxis reduce the incidence of postoperative atrial tachyarrhythmias and major cardiovascular events in patients undergoing cardiac surgery?
Population
10 trials involving 1,744 patients undergoing cardiac surgery
Comparison
Amiodarone prophylaxis vs Placebo
Design
Meta-analysis, Randomized, Double-blind
Authors
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Supports perioperative amiodarone to reduce AF, VT/VF, stroke, and LOS after cardiac surgery; strengthens evidence from randomized trials.
Does amiodarone prophylaxis reduce the incidence of postoperative atrial tachyarrhythmias and major cardiovascular events in patients undergoing cardiac surgery?
Amiodarone prophylaxis significantly reduces postoperative atrial fibrillation, ventricular arrhythmias, stroke, and hospital length of stay in patients undergoing cardiac surgery.
Aasbo et al. (2005) studied this question.
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