Key result
Oral amiodarone prophylaxis significantly reduced the incidence of atrial tachyarrhythmias after cardiac surgery compared to placebo (16.1% vs 29.5%; HR 0.52; 95% CI 0.34-0.69; P<.001).
Why the study?
Does a brief perioperative course of prophylactic oral amiodarone reduce the incidence of atrial tachyarrhythmias after nonemergent CABG or valve surgery?
Population
601 patients listed for nonemergent coronary artery bypass graft surgery and/or valve replacement/repair…
Comparison
Oral amiodarone administered 6 days prior to… vs Placebo administered 6 days prior to surgery…
Design
RCT, Randomization was stratified for subgroups defined by age, type of…
Follow-up
1 year
Authors
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Supports brief perioperative oral amiodarone in nonemergent cardiac surgery; reinforces RCT evidence for postoperative atrial tachyarrhythmia prevention.
RCT (n=601)
Double-blind
Stratified
No
Does a brief perioperative course of prophylactic oral amiodarone reduce the incidence of atrial tachyarrhythmias after nonemergent CABG or valve surgery?
Effect estimate: HR 0.52 (95% CI 0.34-0.69)
Absolute Event Rate: 16.1% vs 29.5%
p-value: p=<.001
A brief perioperative course of oral amiodarone significantly reduces the incidence of postoperative atrial tachyarrhythmias in patients undergoing nonemergent cardiac surgery.
Mitchell et al. (2005) conducted an RCT in Patients undergoing nonemergent CABG and/or valve replacement/repair surgery (n=601). Oral amiodarone vs. Placebo was evaluated on Incidence of atrial tachyarrhythmias lasting 5 minutes or longer that prompted therapy by the sixth postoperative day (HR 0.52, 95% CI 0.34-0.69, p=<.001). Oral amiodarone prophylaxis significantly reduced the incidence of atrial tachyarrhythmias after cardiac surgery compared to placebo (16.1% vs 29.5%; HR 0.52; 95% CI 0.34-0.69; P<.001).
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