Key result
Transcatheter closure of atrial septal defect significantly decreased right ventricular end-diastolic diameter (43.3 vs 34.9 mm; P<0.001) and TAPSE (29.9 vs 22.4 mm; P<0.001) at 1 month.
Why the study?
Does transcatheter closure of ASD alter right ventricular function indices in patients with secundum-type ASD?
Observational (n=20)
Does transcatheter closure of ASD alter right ventricular function indices in patients with secundum-type ASD?
p-value: p=<0.001
Transcatheter closure of ASD leads to early significant reductions in right heart chamber size and tissue Doppler-derived tricuspid annular velocities, including TAPSE.
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Supports early RV remodeling after ASD closure; hypothesis-generating and requires randomized confirmation before practice change.
Ağaç et al. (2011) conducted an observational in Secundum-type atrial septal defect (n=20). Transcatheter atrial septal defect closure vs. Baseline (pre-closure) was evaluated on Right ventricular function indices including TAPSE and RV end-diastolic diameter (p=<0.001). Transcatheter closure of atrial septal defect significantly decreased right ventricular end-diastolic diameter (43.3 vs 34.9 mm; P<0.001) and TAPSE (29.9 vs 22.4 mm; P<0.001) at 1 month.
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