Key result
Spirulina maxima administration significantly decreased systolic blood pressure, sVCAM-1, sE-selectin, and endothelin-1 levels (p < 0.05) in patients with systemic arterial hypertension.
Why the study?
Spirulina maxima has shown beneficial effects including antihypertensive and antioxidant properties, but clinical studies are few and limited.
Does Spirulina maxima improve endothelial damage and oxidative stress indicators in patients with systemic arterial hypertension treated with ACE inhibitors?
RCT (n=16)
randomized
Does Spirulina maxima improve endothelial damage and oxidative stress indicators in patients with systemic arterial hypertension treated with ACE inhibitors?
p-value: p=< 0.05
Spirulina maxima supplementation may improve endothelial damage and oxidative stress indicators, as well as lower systolic blood pressure, in patients with systemic arterial hypertension on ACE inhibitors.
Spirulina maxima may adjunctively lower SBP and endothelial markers in ACE inhibitor-treated hypertension; extends RCT evidence for nutraceuticals in this setting.
(1) Background: Spirulina (Arthrospira) maxima has shown beneficial effects such as being anti-dyslipidemic, antiviral, antioxidant and antihypertensive. However, there are few and limited clinical studies. (2) Methods: a prospective, randomized, parallel pilot study of 4.5 g administration of Spirulina maxima or placebo for 12 weeks in 16 patients with systemic arterial hypertension (SAH) undergoing treatment with angiotensin-converting enzyme (ACE) inhibitors was performed to assess the effects on endothelial damage and oxidative stress indicators. The blood levels of sICAM-1, sVCAM-1, endothelin-1, and sE-selectin were quantified; the activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and concentrations of reduced glutathione, oxidized glutathione, and thiobarbituric acid reactive substances, were also quantified before and after the treatment period. (3) Results: There were statistically significant (p < 0.05) decreases in systolic blood pressure, sVCAM-1, sE-selectin and endothelin-1 levels, and increases in glutathione peroxidase activity and oxidized glutathione levels. (4) Conclusion: The effects found in the present study agree with antihypertensive and antioxidant effects previously reported for Spirulina maxima. However, this is the first report about the effects on indicators of endothelial damage. More research in this field is necessary to gain an insight into the effects of Spirulina on these indicators.
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Martínez-Sámano et al. (2018) conducted an RCT in systemic arterial hypertension (n=16). Spirulina maxima vs. placebo was evaluated on Endothelial damage and oxidative stress indicators (p=< 0.05). Spirulina maxima administration significantly decreased systolic blood pressure, sVCAM-1, sE-selectin, and endothelin-1 levels (p < 0.05) in patients with systemic arterial hypertension.
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