Key result
High resting heart rate combined with high BMI was associated with significantly greater odds of a high SYNTAX score in patients with stable angina (OR 4.03; 95% CI 2.00-8.14).
Why the study?
Are high resting heart rate and high BMI associated with a higher SYNTAX score in patients with stable angina pectoris?
Observational (n=312)
Are high resting heart rate and high BMI associated with a higher SYNTAX score in patients with stable angina pectoris?
Odds Ratio: 4.03 (95% CI 2–8.14)
High resting heart rate and high BMI are independent and combined predictors of severe coronary atherosclerosis burden in patients with stable angina.
May support combined risk stratification in stable angina; hypothesis-generating and requires prospective validation before guiding care.
We investigated the independent and combined association of resting heart rate (RHR expressed as beats/min, bpm) and body mass index (BMI) with SYNTAX score (SS) in patients with stable angina. We divided 312 patients into 4 groups according to RHR quartiles: Q1 (<65 bpm), Q2 (65-69 bpm), Q3 (70-79 bpm), and Q4 (≥80 bpm). The SS (12.0 ± 9.0, 16.0 ± 15.5, 18.0 ± 16.5, and 20.0 ± 27.5; P < .001) was significantly higher for those in Q4 than for those in Q1, Q2, and Q3. Multivariate logistic regression analysis indicated that each 10-bpm increment in RHR was significantly associated with SS (odds ratio [OR] 1.62, 95% confidence interval [CI] 1.27-2.06). Patients with high RHR and high BMI had significantly greater odds ratio (OR) of high SS (4.03, 95% CI 2.00-8.14), compared to participants with low RHR and low BMI. Both RHR and BMI were independent predictors of coronary atherosclerosis as assessed by SS. RHR in combination with BMI and multivariate logistic regression analysis emphasized the importance of the correlation between RHR and SS in patients with stable angina pectoris.
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Zhang et al. (2017) conducted an observational in stable angina pectoris (n=312). High resting heart rate and high BMI vs. Low resting heart rate and low BMI was evaluated on High SYNTAX score (OR 4.03, 95% CI 2.00-8.14). High resting heart rate combined with high BMI was associated with significantly greater odds of a high SYNTAX score in patients with stable angina (OR 4.03; 95% CI 2.00-8.14).
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