Key result
Elevated resting heart rate in the highest quintile was significantly associated with increased odds of having metabolic syndrome in both men (OR 4.2) and women (OR 3.6) compared to the lowest quintile.
Cross-Sectional (n=7,706)
No
Odds Ratio: 4.2 (95% CI 3–5.9)
Absolute Event Rate: 21.1% vs 6.2%
p-value: p=<0.01
Elevated resting heart rate is strongly and independently associated with the presence of the metabolic syndrome in apparently healthy individuals, suggesting a shared pathophysiological mechanism.
No immediate practice change; leaves open causal direction and need for longitudinal confirmation.
BACKGROUND: Increased resting heart rate (RHR) may be associated with increased cardiovascular morbidity. Our aim was to explore the possibility that increased RHR is associated with the prevalence of the metabolic syndrome (MetS) in a sample of apparently healthy individuals and those with cardiovascular risk factors. METHODS: We performed a cross-sectional analysis in a large sample of apparently healthy individuals who attended a general health screening program and agreed to participate in our survey. We analyzed a sample of 7706 individuals (5106 men and 2600 women) with 13.2% of men and 8.9% of the women fulfilling the criteria for the MetS. The participants were divided into quintiles of resting heart rate. Multiple adjusted odds ratio was calculated for having the MetS in each quintile compared to the first. RESULTS: The multi-adjusted odds for the presence of the MetS increased gradually from an arbitrarily defined figure of 1.0 in the lowest RHR quintile (<60 beats per minute (BPM) in men and <64 BPM in women) to 4.1 and 4.2 in men and women respectively in the highest one (>or=80 BPM in men and >or=82 BPM in women). CONCLUSION: Raised resting heart rate is significantly associated with the presence of MetS in a group of apparently healthy individuals and those with an atherothrombotic risk. The strength of this association supports the potential presence of one or more shared pathophysiological mechanisms for both RHR and the MetS.
No takes yet. Share an insight, caveat, or question.
Rogowski et al. (2009) conducted a cross-sectional in Metabolic Syndrome (n=7,706). Elevated resting heart rate (highest quintile) vs. Lowest resting heart rate quintile was evaluated on Presence of the metabolic syndrome (MetS) (OR 4.2, 95% CI 3.0-5.9, p=<0.01). Elevated resting heart rate in the highest quintile was significantly associated with increased odds of having metabolic syndrome in both men (OR 4.2) and women (OR 3.6) compared to the lowest quintile.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: