Key result
Sedation with a ketamine-dexmedetomidine mixture during regional anesthesia for anorectal malformation correction in 4 infants resulted in no respiratory depression or hemodynamic instability.
Why the study?
In low-income countries, surgical and anesthetic management of anorectal malformations in children is challenging due to limited oxygen, equipment, and intensive care units.
Case Report (n=4)
A ketamine-dexmedetomidine combination provided safe sedation without respiratory depression or hemodynamic instability in a small series of pediatric patients undergoing major surgery in a low-resource setting.
Offers preliminary support for ketamine-dexmedetomidine sedation in infants; hypothesis-generating and should not change practice without further study.
Anorectal malformations are one of the most frequent congenital malformations treated by pediatric surgeons. In low-income countries, the surgical and anesthetic management of children in need of these procedures can be challenging. Limited oxygen supply, lack of equipment, especially pediatric, and intensive care units make the use of regional anesthesia appealing. We present a series of four cases of anorectal malformations corrections in Guinea Bissau, in children up to 13 months of age, under regional anesthesia and sedation with ketodex, a mixture of ketamine and dexmedetomidine (in a proportion of 1 mg to 1 μg). No child developed respiratory depression requiring airway intervention or supplemental oxygen, or had hemodynamic instability.
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Tavares et al. (2022) conducted a case report in Anorectal malformations (n=4). Ketodex (ketamine and dexmedetomidine mixture) with regional anesthesia was evaluated on Respiratory depression requiring airway intervention or supplemental oxygen, or hemodynamic instability. Sedation with a ketamine-dexmedetomidine mixture during regional anesthesia for anorectal malformation correction in 4 infants resulted in no respiratory depression or hemodynamic instability.
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