Key result
The pri-let-7f-2 rs17276588 A allele significantly increased the risk of ischemic stroke compared to the G allele in a Chinese Han population (OR 4.654 in males).
Why the study?
Stroke is a leading cause of disability and death worldwide, highlighting the need to identify individuals at risk of developing ischemic stroke using readily available clinical variables.
Does the pri-let-7f-2 rs17276588 variant genotype predict the risk of ischemic stroke in a Chinese Han population?
Population
1,803 ischemic stroke patients and 1,456 healthy controls from Liaoning, China
Comparison
Pri-let-7f-2 rs17276588 variant genotypes
Design
Case-control study
Authors
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May support nomogram-based risk prediction in Chinese Han males; leaves open prospective validation before clinical adoption.
Case-Control (n=3,259)
No
Does the pri-let-7f-2 rs17276588 variant genotype predict the risk of ischemic stroke in a Chinese Han population?
Odds Ratio: 4.654 (95% CI 3.536–6.126)
p-value: p=<0.001
The pri-let-7f-2 rs17276588 variant genotype is a significant independent risk factor for ischemic stroke in the Chinese Han population and can be incorporated into a predictive nomogram.
Wang et al. (2022) conducted a case-control in Ischemic stroke (n=3,259). pri-let-7f-2 rs17276588 A allele vs. G allele / GG genotype was evaluated on Incidence of ischemic stroke (OR 4.654, 95% CI 3.536-6.126, p=<0.001). The pri-let-7f-2 rs17276588 A allele significantly increased the risk of ischemic stroke compared to the G allele in a Chinese Han population (OR 4.654 in males).
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