Population
Hepatitis C virus (HCV) and related viruses (GBV-B, GBV-C, bovine viral diarrhea virus) NS5A proteins
Design
Preclinical
Authors
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Supports NS5A amphipathic helix as pan-Flaviviridae antiviral target; leaves open clinical translation pending human studies.
Membrane association of NS5A by an N-terminal amphipathic alpha helix is a conserved feature among HCV and related Flaviviridae viruses, essential for replication complex formation.
Brass et al. (2006) studied this question.
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