Key result
Type 1 diabetes mellitus is associated with a proinflammatory and procoagulant state that may contribute to the development of chronic vascular complications.
Type 1 diabetes induces a procoagulant and proinflammatory state that increases the risk of cardiovascular and microvascular complications.
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Supports closer vascular monitoring in type 1 diabetes; leaves open whether targeting inflammation or coagulation improves outcomes.
This review summarizes current knowledge of the adverse effects of type 1 diabetes mellitus on coagulation and fibrinolysis. Although further larger studies are needed to provide more definitive information, patients with type 1 diabetes exhibit a proinflammatory/procoagulant condition deriving from increased platelet adhesiveness, activation of the coagulation system, and decreased plasma fibrinolytic potential. This review also focuses on recent data from large prospective studies suggesting a strong association between procoagulant imbalance and development of chronic vascular complications in people with type 1 diabetes. It is likely that a greater appreciation of the intimate interactions between endothelial integrity, coagulation and fibrinolytic factors, and platelets in type 1 diabetes will provide a greater understanding of the risk of developing cardiovascular disease and microvascular complications such as nephropathy and retinopathy in this patient population.
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Targher et al. (2011) conducted a review in Type 1 Diabetes Mellitus. Type 1 diabetes mellitus was evaluated. Type 1 diabetes mellitus is associated with a proinflammatory and procoagulant state that may contribute to the development of chronic vascular complications.
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