Key result
Age-dependent histological differences were observed in Becker muscular dystrophy, with active necrosis prominent in patients ≤15 years and chronic myopathic changes evident in those >15 years.
Population
20 patients with Becker muscular dystrophy (BMD), confirmed by dystrophin tests
Comparison
Muscle histology evaluation vs Younger vs older patients
Design
Cross-sectional
Authors
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May refine age-adjusted biopsy interpretation in Becker muscular dystrophy; hypothesis-generating for progression and trial endpoints.
Observational (n=20)
Muscle histology in Becker muscular dystrophy shows age-dependent differences, with active necrosis in younger patients and chronic myopathic changes in older patients.
Kaido et al. (1991) conducted an observational in Becker muscular dystrophy (n=20). Older age (>15 years) vs. Younger age (≤15 years) was evaluated on Morphological differences in muscle histology. Age-dependent histological differences were observed in Becker muscular dystrophy, with active necrosis prominent in patients ≤15 years and chronic myopathic changes evident in those >15 years.
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