Key result
Genetically engineered mice lacking the desmin gene generated lower stress but experienced less injury during intense exercise, despite tremendous disorganization of the myofibrillar lattice.
The intermediate filament protein desmin is crucial for myofibrillar organization and force transmission, and its absence alters the muscle's response to intense exercise.
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Should not change clinical practice in muscle disorders; hypothesis-generating for desmin's role in exercise injury from animal data alone.
Lieber et al. (2002) studied Eccentric contraction-induced muscle injury. Lack of desmin gene was evaluated on Muscle injury and myofibrillar lattice organization. Genetically engineered mice lacking the desmin gene generated lower stress but experienced less injury during intense exercise, despite tremendous disorganization of the myofibrillar lattice.
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