The effect of different chemical reagents on renin has been investigated. After treatment of hog renin with acetic anhydride, 1-fluoro-2,4-dinitrobenzene, diazobenzene sulfonic acid and phenyl isocyanate, the enzymic activity assayed both biologically and chemically was depressed, whereas no effect occurred after treatment with diisopropyl fluorophosphate, p-chloromercuribenzoate and after dialysis against EDTA. Human renin, too, is inactivated by acetylation, diazo coupling and dinitrobenzoylation. The results indicate that one or several amino groups of the renin molecule are essential for enzymic activity.
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Reinharz et al. (2017) studied this question.
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