Previous reports frmm various laboratories have ances of protein metabolism, which emphasized the failure to demonstrate consistent and significant biochenjicalchanages during hepatic coma (1-3). However, a cross increase of amino acids in the plasma, urine and spinal fluid (4, 5) and an elevation of ammonia in the blood (6-9) have been observed to accompany hepatic coma. Since diseases of the liver often result in disturb- ' The Mayo Foundation, Rochester, Minnesota, is a part of the Graduate School of the University of Min- nesota.
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Wu et al. (1955) studied this question.