Key result
Thyrotoxic periodic paralysis is characterized by abrupt hypokalemia and paralysis secondary to thyrotoxicosis, resulting from an intracellular shift of potassium rather than total body depletion.
Thyrotoxic periodic paralysis is characterized by hypokalemia and paralysis due to an intracellular potassium shift, most commonly affecting Asian men.
Alerts clinicians to avoid over-repletion in shift-induced hypokalemia; review leaves prospective management trials open.
Thyrotoxic periodic paralysis (TPP) is characterized by abrupt onset of hypokalemia and paralysis. This condition primarily affects the lower extremities but may affect both upper and lower extremities and is secondary to thyrotoxicosis. It is most commonly seen in Asian men and it has been increasingly reported in USA due to the rise in the immigrant population. Hypokalemia in TPP results from an intracellular shift of potassium induced by the thyroid hormone sensitization of Na+/K+ATPase rather than depletion of total body potassium.
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Alam et al. (2016) conducted a review in Thyrotoxic periodic paralysis (TPP). Thyrotoxic periodic paralysis is characterized by abrupt hypokalemia and paralysis secondary to thyrotoxicosis, resulting from an intracellular shift of potassium rather than total body depletion.
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