Key result
Intravenous 25 mg chlorpromazine in a thermoneutral environment significantly decreased plasma noradrenaline (average fall 4.42 nmol/L) and adrenaline (average fall 1.06 nmol/L) (P<0.01).
Why the study?
Does intravenous chlorpromazine alter plasma catecholamine levels in humans in a horizontal, thermoneutral environment?
Does intravenous chlorpromazine alter plasma catecholamine levels in humans in a horizontal, thermoneutral environment?
Effect estimate: Average fall: 4.42 nmol/L (noradrenaline) and 1.06 nmol/L (adrenaline)
p-value: p=<0.01
Treatment with alpha adrenergic receptor blocking agents like chlorpromazine can be performed without increasing plasma catecholamines, provided baro-reflex activation and nonshivering thermogenesis are avoided.
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Chlorpromazine was associated with reduced catecholamines in thermoneutral settings; leaves open effects during routine alpha-blockade.
Risbo et al. (1983) studied this question. Chlorpromazine was evaluated on Changes in plasma noradrenaline and plasma adrenaline (Average fall: 4.42 nmol/L (noradrenaline) and 1.06 nmol/L (adrenaline), p=<0.01). Intravenous 25 mg chlorpromazine in a thermoneutral environment significantly decreased plasma noradrenaline (average fall 4.42 nmol/L) and adrenaline (average fall 1.06 nmol/L) (P<0.01).
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