Key result
Alpha-adrenoceptor blockade increased heart rate, cardiac output, and left ventricular ejection fraction, and decreased systemic vascular resistance in 7 healthy men.
Why the study?
Does alpha-adrenoceptor and combined sympathetic and parasympathetic blockade alter cardiac performance and vascular resistance in healthy men?
Does alpha-adrenoceptor and combined sympathetic and parasympathetic blockade alter cardiac performance and vascular resistance in healthy men?
Peripheral vasoconstriction mediated by alpha-adrenoceptor tone in skeletal muscle restricts left ventricular emptying, and combined autonomic blockade at rest augments chronotropy without affecting preload or inotropy.
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Warrants caution before clinical application; leaves open translation of alpha-tone effects to patient populations.
Kelbæk et al. (1992) studied Healthy (n=7). Alpha-adrenoceptor blockade (phentolamine) and combined sympathetic/parasympathetic blockade vs. Baseline (before blockade) was evaluated on Cardiac performance and vascular resistance. Alpha-adrenoceptor blockade increased heart rate, cardiac output, and left ventricular ejection fraction, and decreased systemic vascular resistance in 7 healthy men.
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