Why the study?
Does alpha adrenergic receptor blockade with phentolamine antagonize venous responses to norepinephrine more effectively than arterial responses in humans?
Does alpha adrenergic receptor blockade with phentolamine antagonize venous responses to norepinephrine more effectively than arterial responses in humans?
Alpha adrenergic receptor blockade antagonizes constriction of capacitance vessels more effectively than constriction of resistance vessels.
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Supports differential alpha-blockade on capacitance versus resistance vessels; leaves open clinical translation in cardiovascular disease.
Abboud et al. (1968) studied this question.
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