Why the study?
Does intravenous propranolol reduce central sympathetic outflow in healthy young subjects?
Population
18 healthy controls (14 male, 4 female; mean age 26+/-6 years, body mass index 23+/-3 kg/m2)
Comparison
Propranolol 0.21 mg/kg total intravenous dose… vs Baseline measurements before beta-blockade
Design
Other
Follow-up
acute
Authors
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Acute propranolol increased MSNA in healthy subjects; leaves open central beta-receptor effects on sympathetic outflow and should not change practice.
Does intravenous propranolol reduce central sympathetic outflow in healthy young subjects?
Intravenous propranolol does not acutely decrease sympathetic activity in healthy young subjects, challenging the concept of a major tonic stimulatory effect of central beta-adrenoreceptors.
Tank et al. (2001) studied this question.
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