Differential effects of β‐adrenoreceptor antagonists on central and peripheral blood pressure at rest and during exercise
Why the study?
Do beta-blockers (propranolol and bisoprolol) reduce central and peripheral blood pressure at rest and during exercise in healthy volunteers?
Population
20 healthy normotensive volunteers (18 men, aged 19-54 years)
Comparison
Propranolol 80 mg and bisoprolol 20 mg… vs Placebo administered 1 hour before bicycle…
Design
RCT, randomized, cross-over
Follow-up
acute (during exercise 1 hour post-dose)
Authors
Discussion
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Member takes
Implication
Peripheral SBP reductions with beta-blockers during exercise may not reflect central effects; extends evidence of differential arterial hemodynamics.
Structured PICO
Do beta-blockers (propranolol and bisoprolol) reduce central and peripheral blood pressure at rest and during exercise in healthy volunteers?
P
Population
20 healthy normotensive volunteers (18 men, aged 19-54 years)
I
Intervention
Propranolol 80 mg and bisoprolol 20 mg administered 1 hour before bicycle ergometry (50, 75 and 100 W each for 3 min)
C
Comparator
Placebo administered 1 hour before bicycle ergometry
O
Outcome
Central and peripheral systolic blood pressure at rest and during exercisesurrogate
Acute beta-blockade reduces peripheral but not central systolic blood pressure during exercise in healthy subjects, suggesting differential effects on arterial hemodynamics.
Cite This Study
Brett et al. (2009) studied this question.