Key result
Intravenous propranolol did not attenuate increases in muscle sympathetic nerve activity during orthostatic stress, despite attenuating increases in regional vascular resistance.
Why the study?
Does intravenous propranolol alter muscle sympathetic nerve activity and vascular resistance during orthostatic stress in healthy humans?
Population
11 healthy humans
Comparison
Propranolol 0.15 mg/kg i.v. vs Baseline measurements before propranolol…
Design
Other
Authors
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Challenges prior assumptions on ventricular mechanoreceptors driving orthostatic sympathetic outflow; leaves open mechanisms of propranolol effects.
Does intravenous propranolol alter muscle sympathetic nerve activity and vascular resistance during orthostatic stress in healthy humans?
Systemic beta-blockade with propranolol causes a marked dissociation between sympathetic outflow and vascular resistance, invalidating its use as an experimental model to examine ventricular mechanoreceptor reflexes in humans.
Jacobsen et al. (1992) studied Healthy (n=11). Propranolol vs. Baseline (pre-administration) was evaluated on Muscle sympathetic nerve activity (MSNA) and regional vascular resistance. Intravenous propranolol did not attenuate increases in muscle sympathetic nerve activity during orthostatic stress, despite attenuating increases in regional vascular resistance.
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