Why the study?
Does propranolol attenuate reflex vasoconstrictor responses to orthostatic stress in normal males?
Population
10 normal males
Comparison
Propranolol 0.1 mg/kg i.v. vs Control state (before propranolol administration)
Design
Other
Authors
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Highlights ventricular baroreceptor role in human orthostatic reflexes; extends mechanistic data but leaves open clinical translation.
Does propranolol attenuate reflex vasoconstrictor responses to orthostatic stress in normal males?
Propranolol selectively attenuates vasoconstrictor responses to orthostatic stress, suggesting ventricular baroreceptors play an important role in reflex adjustments in humans.
Ferguson et al. (1983) studied this question.
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