A N-iodosuccinimide (NIS)-promoted cascade oxoazidation of alkenyl oximes with NaN3 was developed, and a series of azido isoxazoline derivatives were synthesized in good yields. The reactions are easy to be conducted under mild conditions. The mechanism study shows that the reaction might involve a cascade electrophilic iodocyclization/nucleophilic substitution pathway.
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Liu et al. (2023) studied this question.
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