Key result
Heparin therapy is associated with variable and unpredictable risks of hemorrhage and thrombosis, likely due to differences in chemical composition, absorption, and monitoring methods.
Highlights the multiple factors contributing to the variable clinical response and safety profile of heparin therapy.
Demands close heparin monitoring amid unpredictable risks; review leaves open standardization of formulations and methods.
In the past few years concerns have been expressed by clinical investigators regarding the variable and unpredictable risk of both hemorrhage and thrombosis in patients receiving heparin. Recent observations tend to indicate that a number of elements may contribute to variability in response to heparin. Possible factors which may be responsible include differences in chemical composition and in methods of assay, variable absorption, different types and degrees of alteration in coagulation mechanism of patients, and inaccuracies or inadequacies in methods for monitoring therapy.
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William W. Coon (1978) conducted a review in Patients receiving heparin. Heparin was evaluated. Heparin therapy is associated with variable and unpredictable risks of hemorrhage and thrombosis, likely due to differences in chemical composition, absorption, and monitoring methods.
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