Key result
Intravenous insulin infusion and fluid replacement successfully reduced triglyceride levels from 3,117 mg/dL to 642 mg/dL and resolved acute pancreatitis symptoms without the need for plasmapheresis.
Why the study?
Does intravenous insulin infusion and fluid replacement reduce triglyceride levels and improve symptoms in a patient with hypertriglyceridemia-induced acute pancreatitis?
Case Report (n=1)
No
Does intravenous insulin infusion and fluid replacement reduce triglyceride levels and improve symptoms in a patient with hypertriglyceridemia-induced acute pancreatitis?
Intravenous insulin infusion and fluid replacement successfully reduced severe hypertriglyceridemia and resolved acute pancreatitis without the need for plasmapheresis.
Insulin infusion with fluids may offer a plasmapheresis-sparing option in hypertriglyceridemia-induced pancreatitis; this single case leaves the approach unproven.
Hypertriglyceridemia (HTG) is the third most common cause of acute pancreatitis (AP). It is caused by disorders in lipoprotein metabolism due to primary or secondary causes. Metabolic syndrome is also an important factor contributing to the development of HTG. The primary treatment goal in severe HTG is to restore triglyceride levels within normal ranges which can be achieved with lipid lowering drugs mainly fenofibrates, fluid replacement, intravenous insulin infusion and/ or plasmapheresis treatments. Strict diet restricted from fat and simple sugars, exercise and weight control also contribute to HTG control in long term follow up. In this report, a case of severe AP triggered by HTG with other metabolic syndrome components like type 2 diabetes mellitus and obesity is presented.
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Karaaslan et al. (2021) conducted a case report in Acute pancreatitis induced by hypertriglyceridemia (n=1). Intravenous insulin infusion and fluid replacement was evaluated on Triglyceride level reduction. Intravenous insulin infusion and fluid replacement successfully reduced triglyceride levels from 3,117 mg/dL to 642 mg/dL and resolved acute pancreatitis symptoms without the need for plasmapheresis.
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