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All articles of this category The reaction of ethyl glycinate hydrochloride ( 1 ) with 1,3-dicarbonyl compounds 2a-g in presence of triethylamine leads to the formation of ethyl N -(3-oxo-1-alkenyl)glycinates 3a-g . These compounds are easily converted to the pyrroles 4a-g by base-catalyzed intramolecular Knoevenagel condensation.
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Hombrecher et al. (1990) studied this question.
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