Key result
Local production of peptide vasoconstrictors like Angiotensin II and Endothelin-1 modulates autocrine feedback loops and extracellular matrix composition, potentially driving vascular pathologies.
Design
Review
Authors
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May inform vascular disease mechanisms; leaves open whether targeting local peptide production alters outcomes.
Local production of vasoconstrictor peptides like Angiotensin II and Endothelin-1 plays a central role in vessel homeostasis and the pathogenesis of vascular diseases through the regulation of vascular smooth-muscle cell proliferation and extracellular matrix composition.
Hahn et al. (1993) conducted a review in Vascular pathologies. Angiotensin II and Endothelin-1 was evaluated. Local production of peptide vasoconstrictors like Angiotensin II and Endothelin-1 modulates autocrine feedback loops and extracellular matrix composition, potentially driving vascular pathologies.
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