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Various diselenides 1 – 8 have been examined with respect to their glutathione peroxidase-like activities (GPx-activities) as an index of their antioxidant properties. The glutathione oxidase activities of these compounds have also been reviewed reflecting the pro-oxidant properties (GOx-activities) and could be used as an index of cell toxicity. Based on a qualitative structure-activity relationship some trends are suggested.
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Thomas Wirth (1998) studied this question.
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