Key result
Prolonged CPB time, elevated preoperative serum creatinine, emergency surgery, low perfusion pressure, LCOS, age ≥61, prolonged mechanical ventilation, and NYHA class III/IV predicted GIC after CPB.
Why the study?
What are the perioperative risk factors for gastrointestinal complications after cardiopulmonary bypass surgery?
Case-Control (n=412)
What are the perioperative risk factors for gastrointestinal complications after cardiopulmonary bypass surgery?
Identifying perioperative risk factors such as prolonged CPB time and low perfusion pressure can help predict and potentially reduce gastrointestinal complications after cardiopulmonary bypass surgery.
BACKGROUND: Gastrointestinal complications (GIC) after cardiopulmonary bypass (CPB) surgery are rare, but, nevertheless, extremely dangerous.The identification of risks for GIC may be helpful in planning appropriate perioperative management strategies. The aim of the present study was to analyze perioperative factors of GIC in patients undergoing CPB surgery. METHODS: We retrospectively analysed 206 patients who underwent GIC after cardiopulmonary bypass surgery from 2000 to 2007 and compared them with 206 matched control patients (matched for surgery, temperature, hemodilution and date). Univariate analysis and multiple logistic regression analysis were performed on 12 risk factors. RESULT: Sex and types of cardioplegia perfusate did not significantly influence the GIC after CPB surgery. Multiple logistic regression revealed that CPB time, preoperative serum creatinine (PSC) > or = 179 mg/dL, emergency surgery, perfusion pressure < or =40 mmHg, low cardiac output syndrome (LCOS), age > or = 61, mechanical ventilation > or =96 h, New York Heart Association (NYHA) class III and IV were predictors of the occurrence of GIC after CPB surgery. Perfusion pressure and aprotinin administration were protective factors. CONCLUSION: Gastrointestinal complications after CPB surgery could be predictive in the presence of the above risk factors. This study suggests that GIC can be reduced by maintenance of higher perfusion pressure and shortening the time on CPB and ventilation.
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Zhang et al. (2009) conducted a case-control in Gastrointestinal complications after cardiopulmonary bypass surgery (n=412). Perioperative risk factors vs. Matched control patients without gastrointestinal complications was evaluated on Predictors of gastrointestinal complications after CPB surgery. Prolonged CPB time, elevated preoperative serum creatinine, emergency surgery, low perfusion pressure, LCOS, age ≥61, prolonged mechanical ventilation, and NYHA class III/IV predicted GIC after CPB.
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