Key result
Administration of 5 g of idarucizumab effectively reversed the anticoagulant action of dabigatran, improving activated clotting time from 326 seconds to 109 seconds and allowing for successful emergency surgery.
Why the study?
Does idarucizumab effectively reverse the anticoagulant effect of dabigatran in a patient requiring emergency surgery for a ruptured abdominal aortic aneurysm?
Case Report (n=1)
Does idarucizumab effectively reverse the anticoagulant effect of dabigatran in a patient requiring emergency surgery for a ruptured abdominal aortic aneurysm?
Idarucizumab rapidly and effectively reverses the anticoagulant effect of dabigatran, enabling safe emergency surgery for ruptured abdominal aortic aneurysm.
May enable emergency reversal in dabigatran patients; leaves open confirmation in prospective aortic rupture cohorts.
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Kanayama et al. (2020) conducted a case report in Ruptured abdominal aortic aneurysm (n=1). Idarucizumab was evaluated on Activated clotting time (ACT). Administration of 5 g of idarucizumab effectively reversed the anticoagulant action of dabigatran, improving activated clotting time from 326 seconds to 109 seconds and allowing for successful emergency surgery.
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