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The respiratory retention rate for a 2.7-μm aerosol of vesicular stomatitis virus in adult male mice was 41%, with 58% of the retained virus found in the trachea and lung.
The study describes a pressure plethysmograph method for measuring respiratory volume and virus retention in mice exposed to aerosols.
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No direct translation to humans; leaves open refinement of plethysmograph methods for aerosol virus studies in mice.
A pressure plethysmograph for measuring respiratory volume in mice during exposure to virus aerosols is described. The respiratory frequency and tidal volume were measured, and from these data the minute ventilation was calculated. The mean respiratory frequency of adult, male mice was 255 per min; the mean tidal volume of 0.18 ml was inversely related to respiratory frequency. The standardized mean minute ventilation rate was 1.46 ml per g of body weight. The respiratory frequency and tidal volume of CD-1 and HA/ICR strains of mice of the same age were similar. The respiratory retention rate for a 2.7-μm aerosol of vesicular stomatitis virus was 41%, and 58% of the virus retained was found in the trachea and lung.
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Glen A. Fairchild (1972) studied Virus retention studies in mice. Exposure to 2.7-μm aerosol of vesicular stomatitis virus was evaluated on Respiratory retention rate for a 2.7-μm aerosol of vesicular stomatitis virus. The respiratory retention rate for a 2.7-μm aerosol of vesicular stomatitis virus in adult male mice was 41%, with 58% of the retained virus found in the trachea and lung.
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