Key result
Ozone (≤0.45 ppm) inactivated a 1:1000 dilution of poliomyelitis virus in 2 minutes, whereas chlorine and hypochlorite (0.5 ppm) required 180 minutes for inactivation.
Why the study?
Does ozone compared to chlorine inactivate poliomyelitis virus more rapidly?
Does ozone compared to chlorine inactivate poliomyelitis virus more rapidly?
Ozone is a much faster virucidal agent against poliomyelitis virus than chlorine at comparable residual concentrations in vitro.
May support ozone for rapid in vitro poliovirus inactivation; leaves open translation to clinical or water-treatment use.
Gaseous chlorine and hypochlorite in residual amounts of 0.5 ppm failed to inactivate a 1:1000 dilution of Le strain of poliomyelitis virus after an exposure of 90 minutes but inactivated the virus by 180 minutes. These results compare favorably with those of Kempf and Soule in working with the MV strain of virus. 2. Ozone in residual amounts not exceeding 0.45 ppm, inactivated a 1:1000 dilution of Le virus in 2 minutes and a 1:100 dilution of the same virus in 45 minutes. A 1:10 dilution of MV virus was not inactivated in 30 minutes and a 1:10 dilution of Le virus was not inactivated in 45 minutes. The extra amount of brain material in the lower dilutions constitutes an excess of organic matter which probably accounts for the longer time necessary for inactivation of virus at these dilutions.
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Kessel et al. (1943) studied Poliomyelitis Virus. Ozone vs. Gaseous chlorine and hypochlorite (0.5 ppm) was evaluated on Time to virus inactivation. Ozone (≤0.45 ppm) inactivated a 1:1000 dilution of poliomyelitis virus in 2 minutes, whereas chlorine and hypochlorite (0.5 ppm) required 180 minutes for inactivation.
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