Fetal obstructive uropathy.

25 mg sodium fluoride tablets for managing estab- lished vertebral crush fractures.This preparation has been used with success in increasing trabecular bone growth by Mamelle et al, who reported no increase in gastrointestinal disorders compared with a group not given fluoride.To date we have treated eight patients (one man and seven women), none of whom have developed any new epigastric symptoms.All achieved satisfactory serum fluoride concentrations of 150-200 ~tg/l within one month of starting treatment at a daily dose of 50 mg enteric coated sodium fluoride-that is, 22 6mg fluoride ion -supplemented with 1 5 g oral calcium daily and 50 000 U oral vitamin D once a week.Indeed, fluoride absorption has been so efficient that in some patients it has been possible to reduce the dose, based on the serum fluoride concentration two hours after giving the tablets.Although our patients have not undergone gastroscopy to look for mucosal damage, none of them has shown a reduction in haemoglobin concentration or positive results of a faecal occult blood test.This is preliminary experience with enteric coated fluoride, but it is none the less encouraging as an alternative method of giving orally an agent that is effective in the treatment of osteoporosis.