Key result
Low dosage intravenous or oral prostaglandin E in neonates with congenital heart disease resulted in complications in 53% of patients, an incidence similar to high dosage regimens.
Why the study?
Does low dosage intravenous or oral prostaglandin E reduce complications compared to higher doses in neonates with congenital heart disease?
Observational (n=34)
Does low dosage intravenous or oral prostaglandin E reduce complications compared to higher doses in neonates with congenital heart disease?
Low dosage intravenous or oral prostaglandin E is associated with a high incidence of complications similar to high dosages, indicating that its use in any form requires caution.
Low dosage intravenous (< 0.01 micrograms.kg-1.min-1) and oral prostaglandin E have been reported to produce fewer complications than higher intravenous doses in the ductal manipulation of congenital heart disease. Over a 3-year period 34 patients were treated with low dosage intravenous or oral prostaglandin. Eighteen (53%) had complications associated with this treatment with 14 having more than one complication. Major complications occurred in nine neonates: necrotising enterocolitis (7), apnoea/bradycardia (5), convulsions (1), haemorrhage (1), and resulted in a change of management. This study therefore concludes that the high incidence of complications is similar with both low and high dosages of intravenous and oral prostaglandin. The use of prostaglandin in any form deserves caution.
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Singh et al. (1994) conducted an observational in Congenital heart disease (n=34). Low dosage intravenous or oral prostaglandin E vs. High dosages of intravenous prostaglandin (implied/historical) was evaluated on Complications associated with treatment. Low dosage intravenous or oral prostaglandin E in neonates with congenital heart disease resulted in complications in 53% of patients, an incidence similar to high dosage regimens.
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