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April 1, 1983HeartOpen Access

Use of prostaglandin E2 in management of transposition of great arteries before balloon atrial septostomy.

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Why the study?

Does prostaglandin E2 infusion improve oxygenation in infants with transposition of the great arteries and severe hypoxaemia before balloon atrial septostomy?

Population

15 infants with transposition of the great arteries and severe hypoxaemia

Design

Case_series

Follow-up

Up to total correction

Authors

ABA BeitzkeBoston Children's HospitalCSC. SuppanMedical University of Graz

Discussion

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Implication

May support PGE2 consideration in TGA hypoxemia pre-septostomy; hypothesis-generating and requires prospective validation.

Structured PICO

Does prostaglandin E2 infusion improve oxygenation in infants with transposition of the great arteries and severe hypoxaemia before balloon atrial septostomy?

P
Population
15 infants with transposition of the great arteries and severe hypoxaemia (12 with simple transposition, 3 with small ventricular septal defects)
I
Intervention
Prostaglandin E2 infusions before balloon atrial septostomy
O
Outcome
Increase in PaO2 within one to two hourssurrogate

Prostaglandin E2 infusion effectively and rapidly increases PaO2 in infants with transposition of the great arteries and severe hypoxemia prior to balloon atrial septostomy.

Cite This Study

Beitzke et al. (1983) studied this question.

synapsesocial.com/papers/6a7381eb3fd13aec7371af29https://doi.org/10.1136/hrt.49.4.341
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prostaglandin E1 Following Balloon Atrial Septostomy in Dextro-Transposition of the Great Arteries: Reevaluating Dependence, Timing, and Physiology-Guided Management2026
  2. 2Transposition of the Great Arteries with Ventricular Septal Defect1969 · 21 citations
  3. 3Effects of Prostaglandin E1 and Balloon Atrial Septostomy on Cerebral Blood Flow and Oxygenation in Newborns Diagnosed with Transposition of the Great Arteries2024 · 1 citations
  4. 4Anatomic correction of simple transposition of the great arteries in 50 neonates.1987 · 70 citations
  5. 5Balloon Atrial Septostomy in Congenital Heart Disease in Infancy1973 · 9 citations