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June 13, 2026World Journal for Pediatric and Congenital Heart Surgery

Prostaglandin E1 Following Balloon Atrial Septostomy in Dextro-Transposition of the Great Arteries: Reevaluating Dependence, Timing, and Physiology-Guided Management

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Authors

NJNyandat L. JoramManipal Teaching HospitalJNJacqueline Chepng'eno Ng’enyManipal Teaching Hospital

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Implication

Review assesses PGE1 dependence and management timing in neonates with dextro-transposition post-BAS, suggesting a physiology-guided approach.

Key Points

  • The review aims to evaluate the reliance on prostaglandin E1 after balloon atrial septostomy and the timing of its discontinuation.
  • Synthesize clinical evidence and physiological considerations related to PGE1 management after BAS.
  • Analyze predictors of ongoing PGE1 requirement in neonates, including systemic oxygen saturation.
  • Provide recommendations for a physiology-guided approach to PGE1 discontinuation.
  • Postprocedural systemic oxygen saturation and restrictive physiology are strong predictors of continued PGE1 need.
  • Discontinuation of PGE1 too early can lead to rebound hypoxemia, indicating physiological stabilization may be delayed.
  • Continuing PGE1 is safe and beneficial during the transitional phase following BAS.

Cite This Study

Joram et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf500faef96ed7f057193https://doi.org/10.1177/21501351261449200
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between balloon atrial septostomy and prostaglandin E1 therapy until repair of transposition of the great arteries in neonates2024 · 7 citations
  2. 2Incidence and mortality trend of congenital heart disease at the global, regional, and national level, 1990–20172020 · 433 citations
  3. 3Revisiting the Role of Balloon Atrial Septostomy Prior to the Arterial Switch Operation2024 · 5 citations
  4. 4Effects of Prostaglandin E1 and Balloon Atrial Septostomy on Cerebral Blood Flow and Oxygenation in Newborns Diagnosed with Transposition of the Great Arteries2024 · 3 citations
  5. 5Prostaglandin E1 for maintaining ductal patency in neonates with ductal-dependent cardiac lesions2018 · 90 citations