Key result
Continuous infusion of heparin, fresh frozen plasma, and cast immobilization led to DIC improvement and fracture union at 2 years and 3 months in a patient with Parkes-Weber syndrome.
Case Report (n=1)
Conservative management with heparin and fresh frozen plasma successfully treated DIC and allowed fracture union in a patient with Parkes-Weber syndrome.
Answers are grounded in this paper and cite their sources.
Should not change practice; single case leaves open generalizability of heparin infusion for Parkes-Weber DIC and fractures.
Reports of Parkes-Weber syndrome complicated by disseminated intravascular coagulation (DIC) are rare in the orthopaedic literature. This is a case report of a 23-year-old man who had this syndrome and who sustained a lower-leg fracture complicated by the DIC. Open reduction was not attempted because the DIC worsened after manual reduction. Amputation was rejected by the patient. Three months of continuous infusion of heparin and replacement therapy with fresh frozen plasma was done. Cast immobilization without further reductions was continued. The DIC improved and union of the fractures was observed at 2 years and 3 months after injury.
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Yamamoto et al. (1995) conducted a case report in Lower leg fracture with Parkes-Weber syndrome complicated by disseminated intravascular coagulation (n=1). Continuous infusion of heparin, fresh frozen plasma, and cast immobilization was evaluated on DIC improvement and fracture union. Continuous infusion of heparin, fresh frozen plasma, and cast immobilization led to DIC improvement and fracture union at 2 years and 3 months in a patient with Parkes-Weber syndrome.
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