The exocyclic double bond in 5‐arylidene barbituric (3) and thiobarbituric acid (5) derivatives undergoes addition reactions with GRIGNARD reagents yielding the compounds 4 and 6. Also they react with ethereal diazomethane to give the corresponding cyclopropane compounds 7 and 8. Similarly, addition reaction was observed when the compounds 3 and 5 are treated with primary and secondary amines giving 11 and 12, respectively.
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Shalaby et al. (1971) studied this question.
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