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A patient with Cronkhite-Canada syndrome had multiple juvenile colonic polyps with hyperplastic, adenomatous, and mixed villous and adenomatous changes. A Dukes B mucus-secreting adenocarcinoma of the cecum was also present. Currently considered a benign disease, the Cronkhite-Canada syndrome may be a premalignant disorder, as our patient's course suggests. We review the literature in this regard.
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Rappaport et al. (1986) studied this question.
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