Key result
Among children who died from severe hand, foot and mouth disease, fast progressors were significantly younger than slow progressors (mean age 17.4 vs 26.2 months, p<0.01).
Observational (n=331)
Yes
Absolute Event Rate: 17.4% vs 26.2%
p-value: p=<0.01
Mortality in severe hand, foot and mouth disease predominantly affects children under 3 years old with EV71 infection, often driven by brainstem encephalitis leading to rapid cardiopulmonary failure.
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May signal faster deterioration in younger infants with severe HFMD; leaves open age-stratified monitoring trials.
Yang et al. (2017) conducted an observational in Severe Hand, Foot and Mouth Disease (HFMD) (n=331). Fast progression (<4 days from onset to death) vs. Slow progression (≥4 days from onset to death) was evaluated on Mean age of patients (p=<0.01). Among children who died from severe hand, foot and mouth disease, fast progressors were significantly younger than slow progressors (mean age 17.4 vs 26.2 months, p<0.01).
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