Key result
A simple in vivo dog model with induced complete heart block allowed detailed evaluation of the electrophysiological effects of antiarrhythmic agents including flecainide and d-Sotalol.
This simple in vivo dog model allows for detailed evaluation of the electrophysiological effects of antiarrhythmic agents and their combinations.
Provides preclinical platform for antiarrhythmic testing; leaves open translation to human electrophysiology.
Antiarrhythmic agents alter cardiac conduction, refractoriness, and action potential duration in a rate dependent fashion. A simple in vivo model was developed to measure these variables over a wide range of cycle lengths. Complete heart block was produced in dogs using an 8 French hexapolar ablation catheter, anterior skin electrode, and radiofrequency current (30 W, 13.6 +/- 2.6 seconds). Ventricular pacing and monophasic action potential recordings were performed using a single combination catheter. QRS and action potential durations were measured at multiple cycle lengths and after an abrupt change in paced cycle length. Ventricular effective refractory periods were also measured at multiple cycle lengths. Data obtained during flecainide and d-Sotalol infusions are presented. This simple model allows detailed in vivo evaluation of the electrophysiological effects of antiarrhythmic agents and combinations.
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Solomon et al. (1992) studied Complete heart block (induced animal model). In vivo model with flecainide and d-Sotalol infusions was evaluated on QRS duration, action potential duration, and ventricular effective refractory periods. A simple in vivo dog model with induced complete heart block allowed detailed evaluation of the electrophysiological effects of antiarrhythmic agents including flecainide and d-Sotalol.
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