Why the study?
Does alcohol ingestion induce sinus bradycardia and hypotension in patients with syncope and carotid sinus hypersensitivity?
Case Report (n=2)
No
Does alcohol ingestion induce sinus bradycardia and hypotension in patients with syncope and carotid sinus hypersensitivity?
Alcohol ingestion can paradoxically induce sinus bradycardia and hypotension in some patients with syncope and carotid sinus hypersensitivity.
Alcohol may trigger bradycardia and hypotension in alcohol-related syncope; leaves open a mechanistic link to carotid sinus hypersensitivity.
We observed 2 cases of repeated episodes of syncope after alcohol ingestion. Both patients were light drinkers and had carotid sinus hypersensitivity. In both cases, alcohol loading tests repeatedly induced sinus bradycardia and hypotension 1.0-1.5 hours after drinking alcohol. Atropine was effective in improving symptoms. A loading test using a glucose solution of equivalent osmolarity and volume was negative. Acute alcohol ingestion usually increases heart rate with variable effects on blood pressure. However, our 2 cases exhibited unusual alcohol-induced sinus bradycardia and hypotension, suggesting a paradoxical increase in parasympathetic activity and/or decrease in sympathetic activity.
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Tsutsui et al. (1992) conducted a case report in Syncope (n=2). Alcohol loading test vs. Glucose solution of equivalent osmolarity and volume was evaluated on Induction of sinus bradycardia and hypotension.
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