Key result
Recent discoveries highlight that metabolism, redox signaling, and hemodynamic forces act as crucial novel regulators of angiogenesis and vascular homeostasis, offering new potential targets for therapies.
This review summarizes emerging mechanisms in angiogenesis, emphasizing the roles of endothelial metabolism, redox signaling, and hemodynamic forces as potential targets for anti-angiogenic therapies.
Angiogenesis, the formation of new blood vessels, is a unique and crucial biological process occurring during both development and adulthood. A better understanding of the mechanisms that regulates such process is mandatory to intervene in pathophysiological conditions. Here we highlight some recent argument on new players that are critical in endothelial cells, by summarizing novel discoveries that regulate notorious vascular pathways such as Vascular Endothelial Growth Factor (VEGF), Notch and Planar Cell Polarity (PCP), and by discussing more recent findings that put metabolism, redox signaling and hemodynamic forces as novel unforeseen facets in angiogenesis. These new aspects, that critically regulate angiogenesis and vascular homeostasis in health and diseased, represent unforeseen new ground to develop anti-angiogenic therapies.
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Sewduth et al. (2016) conducted a review in Angiogenesis and Vascular Homeostasis. Recent discoveries highlight that metabolism, redox signaling, and hemodynamic forces act as crucial novel regulators of angiogenesis and vascular homeostasis, offering new potential targets for therapies.
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